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Hello

I’m a researcher, advocate, and final-year medical student. I’m interested in protein evolution. More specifically; the structure of proteins, their function, how they evolve by natural selection, and how they got involved in human diseases.
 

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My Story

My keen passion is structural biology. I would like to view myself as a bridge – between cultures, between disciplines, between science and advocacy. My story is one of curiosity, dedication, and a belief in the interconnectedness of all living things. From structures of proteins to hidden tales of evolution, and their profound impact on human health that fuels my every step. 

About Me

I am experienced in non-parametric statistical tests and correlation analysis including non-linear analysis and Kernel regression methods for orthologous sequences generated by Hidden Markov models (HMM). I use an alternative approach to molecular evolution by analyzing the Nash Equilibrium (NE) of the Evolutionary Stable Strategy, without an explicit solution to complex dynamics. For physics-based approaches, I utilize Gibbs free energy calculations considering attractive contributions to the van der Waals interaction energy. I conduct Molecular Dynamics Simulations and Multimer Predictions for both globular and membranous proteins. For the intensive calculations, I am familiar with various supercomputer infrastructures including Google Compute Engine and Colab.

In my perspective, public health largely benefits from open societies and must not be limited to human health alone, given the shared environment and evolutionarily conserved physiology of both humans and other animals. The strategy I follow is collectively known as the One Health approach to public health. 

Recent Experience

2025 Feb - current

Istanbul University Hospital

Intern Doctor med. - Pre-registered Physician

Istanbul University Hospital Clinics


> I am in my last year of Medical School at Istanbul University. I currently work as an intern doctor at the university hospital.

2022 Aug - current

Massachusetts Institute of Technology

Research Collaborator - Part Time

Laboratory of Molecular Architecture, Media Lab, MIT


> Isoforms and alternative mRNA splicing of neurotransmitter transporters
> Heteromerization and contemporary modulator design 
> MSA-based protein structure prediction and computational analysis
> Extensive form games and ESS aplications in molecular evolution
> Structural topology and alpha helices of neuronal transporters 
> Evolutionary Profiling and Natural variants analysis, 
> Protein Secondary Structure Assignment, Helical structure analysis in neuronal transporter proteins

2023 Sept - 2024 March

University College London

Research Collaborator - Part Time

Structural Immunology Group- Darwin Building UCL

> Alternative mRNA splicing and structural alterations in coagulation factors
> Mutational dynamics and epistasis in disease evolution
> Phenotypical profiling and structural prediction

2023 Jan- Aug

University College London Hospitals NHS Foundation Trust 

Guest Scientist - Full Time Visitor

Darwin Building in University College; visitor at UCL Medical School

> Evolutionarily-related proteins in Homo sapiens (Human)
> Genetic variants analysis and molecular mechanisms of related diseases
> Protein Structural Assessment of the effects of genetic variants
> Alternative splicing, and mRNA processing
> Database design with MySQL and HTML programming

Education

2023

pre-MD research

2023

Guest Scientist

2019-2026

Medical Degree - MD

Istanbul University, English Medical Program

Structural Immunology Group- Darwin Building UCL

Laboratory of Molecular Architecture, Media Lab, MIT

Contact

I'm always looking for new and exciting opportunities. Let's connect.

Confused? Go to my twin's website >> www.tanerkaragol.com

The views and opinions expressed on this website are solely my own and do not reflect the views, policies, or positions of any institution, organization, or entity with which I am or have been affiliated.

Nothing on this website should be construed as professional, legal, or official advice. 

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